Title: Park Nucleotide
CAS Registry Number: 18836-50-5 (L-lysyl form); 120010-32-4 (pimelate form)
Additional Names: UDP-MurNAc-L-Ala-g-D-Glu-X-D-Ala-D-Ala; stem peptide
Literature References: Glyco-pentapeptide; key intermediate in bacterial cell-wall synthesis. Residue 3 varies from species to species; it is usually L-Lys in Gram positive bacteria and mesodiaminopimelate in Gram negative bacteria. Identification and isolation from Staphylococcus aureus: J. T. Park, J. Biol. Chem. 194, 885 (1952). Total synthesis: S. A. Hitchcock et al., J. Am. Chem. Soc. 120, 1916 (1998); of radioiodinated analog: C. N. Eid et al., J. Labelled Compd. Radiopharm. 41, 705 (1998).
Use: Tool for antibacterial screen development. |