Title: Onapristone
CAS Registry Number: 96346-61-1
CAS Name: (11b,13a,17a)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)estra-4,9-dien-3-one
Additional Names: 11b-(4-dimethylaminophenyl)-17a-hydroxy-17b-(3-hydroxypropyl)-13a-methyl-4,9-gonadien-3-one
Manufacturers' Codes: ZK-98299
Molecular Formula: C29H39NO3
Molecular Weight: 449.62
Percent Composition: C 77.47%, H 8.74%, N 3.12%, O 10.68%
Literature References: Progesterone receptor antagonist. Prepn: G. Neef et al., EP 129499; eidem, US 4780461 (1984, 1988 both to Schering AG); idem et al., Steroids 44, 349 (1984). HPLC determn in plasma and serum: C. Zurth, F. Kagels, J. Chromatogr. 532, 115 (1990). In vitro effect on breast cancer cells: S. Classen et al., J. Steroid Biochem. Mol. Biol. 45, 315 (1993). Mechanism of action study: D. P. Edwards et al., ibid. 53, 449 (1995). Clinical antifolliculotrophic effect: H. B. Croxatto et al., Hum. Reprod. 9, 1442 (1994).
Properties: Amorphous glass. [a]D25 +446.2° (c = 0.51 in chloroform).
Optical Rotation: [a]D25 +446.2° (c = 0.51 in chloroform)
Therap-Cat: Antiprogestin; antineoplastic (hormonal).
Keywords: Antineoplastic (Hormonal); Antiprogestins; Antiprogestin. |