Title: Norgestrienone
CAS Registry Number: 848-21-5
CAS Name: (17a)-17-Hydroxy-19-norpregna-4,9,11-trien-20-yn-3-one
Additional Names: 17a-ethynyl-4,9,11-estratrien-17b-ol-3-one; 17a-ethynyl-17b-hydroxy-3-oxo-4,9,11-estratriene; 17a-ethynyl-13b-methyl-D4,9,11-gonatriene-17b-ol-3-one
Trademarks: Ogyline (Roussel Diamant)
Molecular Formula: C20H22O2
Molecular Weight: 294.39
Percent Composition: C 81.60%, H 7.53%, O 10.87%
Literature References: Prepn: NL 6401555, corresp to Nominé et al., US 3257278 (1964 and 1966, both to Roussel-UCLAF); Nominé et al., Compt. Rend. 260, 4545 (1965); FR M3060 and NL 6517141 (1965 and 1966, both to Roussel-UCLAF), C.A. 63, 8449b (1965) and 65, 15470b (1966).
Properties: Pale yellow needles from diisopropyl ether, mp 169°. [a]D20 +63° (c = 0.5 in alc). uv max: 342, 238 nm (e 29100, 5920). Sol in alcohols, ether, acetone, benzene, chloroform; practically insol in water, dil aq acids and alkalies.
Melting point: mp 169°
Optical Rotation: [a]D20 +63° (c = 0.5 in alc)
Absorption maximum: uv max: 342, 238 nm (e 29100, 5920)
Therap-Cat: Progestogen.
Keywords: Progestogen. |