Title: Methaphenilene
CAS Registry Number: 493-78-7
CAS Name: N,N-Dimethyl-N¢-phenyl-N¢-(2-thienylmethyl)-1,2-ethanediamine
Additional Names: N,N-dimethyl-N¢-phenyl-N¢-(2-thenyl)ethylenediamine
Manufacturers' Codes: 00836; RP-2740; W-50 base
Trademarks: Diatrin base (Warner-Chilcott)
Molecular Formula: C15H20N2S
Molecular Weight: 260.40
Percent Composition: C 69.19%, H 7.74%, N 10.76%, S 12.31%
Literature References: Prepd by a sodamide condensation of N,N-dimethyl-N¢-phenylethylenediamine with 2-thenyl chloride in dry toluene: Leonard, Solmssen, J. Am. Chem. Soc. 70, 2066 (1948). Pharmacology and toxicology: N. Ercoli et al., J. Pharmacol. Exp. Ther. 93, 210 (1948).
Properties: Dark yellow oil. bp7 183-185°. nD25 1.5902.
Boiling point: bp7 183-185°
Index of refraction: nD25 1.5902
Derivative Type: Hydrochloride
CAS Registry Number: 7084-07-3
Trademarks: Diatrin; Enstamine; Nilhistin
Molecular Formula: C15H20N2S.HCl
Molecular Weight: 296.86
Percent Composition: C 60.69%, H 7.13%, N 9.44%, S 10.80%, Cl 11.94%
Properties: Crystals from ethanol, mp 186-187°. Freely soluble in water. Soluble in alc. LD50 in mice, guinea pigs (mg/kg): 45, 30 i.v.; 160, 140 s.c.; 550, 900 orally; in rabbits (mg/kg): 30 i.v. (Ercoli).
Melting point: mp 186-187°
Toxicity data: LD50 in mice, guinea pigs (mg/kg): 45, 30 i.v.; 160, 140 s.c.; 550, 900 orally; in rabbits (mg/kg): 30 i.v. (Ercoli)
Therap-Cat: Antihistaminic.
Therap-Cat-Vet: Antihistaminic.
Keywords: Antihistaminic; Ethylenediamine Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update. |