Title: Isbogrel
CAS Registry Number: 89667-40-3
CAS Name: (E)-7-Phenyl-7-(3-pyridinyl)-6-heptenoic acid
Manufacturers' Codes: CV-4151
Molecular Formula: C18H19NO2
Molecular Weight: 281.35
Percent Composition: C 76.84%, H 6.81%, N 4.98%, O 11.37%
Literature References: Thromboxane A2 (TXA2) synthetase inhibitor. Prepn: S. Terao, K. Nishikawa, EP 98690; eidem, US 4518602 (1984, 1985 both to Takeda); and inhibition of TXA2: K. Kato et al., J. Med. Chem. 28, 287 (1985). Pharmacology: Z. Terashita et al., Thromb. Res. 41, 223 (1986). Antithrombotic effect in experimental thrombi: T. Matsubara et al., Am. Heart J. 118, 837 (1989). Clinical pharmacokinetics: T. Kuzuya et al., Cardiovasc. Drugs Ther. 2, 693 (1988). Clinical trial: R. Hattori et al., Jpn. Circ. J. 55, 324 (1991).
Properties: mp 114-115°.
Melting point: mp 114-115°
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic; Thromboxane A2-Sythetase Inhibitor.
Status: This monograph has been retired and is no longer subject to revision or update. |