Title: Indaconitine
CAS Registry Number: 4491-19-4
CAS Name: 16-Ethyl-1,6,19-trimethoxy-4-(methoxymethyl)aconitane-3,8,10,11-tetrol 8-acetate 10-benzoate
Additional Names: acetylbenzoylpseudaconine
Molecular Formula: C34H47NO10
Molecular Weight: 629.74
Percent Composition: C 64.85%, H 7.52%, N 2.22%, O 25.41%
Literature References: From root of Aconitum chasmanthum Stapf. Ranunculaceae: Dunstan, Andrews, J. Chem. Soc. 87, 1620 (1905). Structure: Gilman, Marion, Can. J. Chem. 42, 2700 (1964).
Properties: Needles from ether, mp 202-203°. [a]D21 +18.28° (c = 2.18 in alc). Indaconitine and its salts are highly toxic: Cash, Dunstan, Proc. Roy. Soc. (London) B176, 468 (1905). Sol in acetone, chloroform, alcohol, ether; practically insol in water, petr ether.
Melting point: mp 202-203°
Optical Rotation: [a]D21 +18.28° (c = 2.18 in alc)
Derivative Type: Hydrobromide
Properties: Prisms from water, mp 183-187°; mp 217-218° from alcohol + ether. [a]D -17.27° (c = 2.991).
Melting point: mp 183-187°; mp 217-218° from alcohol + ether
Optical Rotation: [a]D -17.27° (c = 2.991)
Derivative Type: Hydrochloride trihydrate
Properties: Needles from alcohol + ether. Anhydr salt mp 166-171°. Very hygroscopic. [a]D20 -15.83° (c = 1.921).
Melting point: mp 166-171°
Optical Rotation: [a]D20 -15.83° (c = 1.921)
Status: This monograph has been retired and is no longer subject to revision or update. |