Title: Incadronic Acid
CAS Registry Number: 124351-85-5
CAS Name: [(Cycloheptylamino)methylene]bisphosphonic acid
Molecular Formula: C8H19NO6P2
Molecular Weight: 287.19
Percent Composition: C 33.46%, H 6.67%, N 4.88%, O 33.43%, P 21.57%
Literature References: Bisphosphonate antiresorptive agent. Prepn: Y. Isomura et al., EP 325482; eidem, US 4970335 (1989, 1990 both to Yamanouchi); M. Takeuchi et al., Chem. Pharm. Bull. 41, 688 (1993). HPLC determn in plasma, urine and bone: T. Usui et al., J. Chromatogr. 584, 213 (1992). Effect on bone mineral density in dogs: H. Motoie et al., J. Bone Miner. Res. 10, 910 (1995). Toxicology: A. Okazaki et al., J. Toxicol. Sci. 20, Suppl. 1, 15 (1995). Clinical pharmacokinetics: T. Usui et al., Int. J. Clin. Pharmacol. Ther. 35, 239 (1997). Clinical evaluation in hypercalcemia of malignancy: S. Fukumoto et al., J. Clin. Endocrinol. Metab. 79, 165 (1994).
Properties: Crystals from methanol-water, mp 232-233°.
Melting point: mp 232-233°
Derivative Type: Disodium salt
CAS Registry Number: 138330-18-4
Additional Names: Cimadronate sodium; incadronate sodium
Manufacturers' Codes: YM-175
Trademarks: Bisphonal (Yamanouchi)
Molecular Formula: C8H17NNa2O6P2
Molecular Weight: 331.15
Percent Composition: C 29.02%, H 5.17%, N 4.23%, Na 13.88%, O 28.99%, P 18.71%
Properties: Occurs as the monohydrate. White, odorless crystalline powder. Easily sol in water. LD50 in male, female rats (mg/kg): 23, 21 i.v. (Okazaki).
Toxicity data: LD50 in male, female rats (mg/kg): 23, 21 i.v. (Okazaki)
Therap-Cat: Bone resorption inhibitor.
Keywords: Antiosteoporotic; Bone Resorption Inhibitor. |