Title: Ibufenac
CAS Registry Number: 1553-60-2
CAS Name: 4-(2-Methylpropyl)benzeneacetic acid
Additional Names: (p-isobutylphenyl)acetic acid; p-isobutyl-a-toluic acid
Trademarks: Dytransin; Ibunac (Kaken)
Molecular Formula: C12H16O2
Molecular Weight: 192.25
Percent Composition: C 74.97%, H 8.39%, O 16.64%
Literature References: Prepn: J. S. Nicholson, S. S. Adams, GB 971700; eidem, US 3385887 (1964, 1968 both to Boots Pure Drug). Pharmacology: S. S. Adams et al., J. Pharm. Pharmacol. 20, 305 (1968). Toxicity data: S. S. Adams et al., Nature 200, 271 (1962).
Properties: Crystals, mp 85-87°. Very slightly sol in water. Freely sol in many organic solvents. LD50 orally in mice: 1.8 g/kg (Adams).
Melting point: mp 85-87°
Toxicity data: LD50 orally in mice: 1.8 g/kg (Adams)
Therap-Cat: Analgesic, anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives. |