Title: Halometasone
CAS Registry Number: 50629-82-8
CAS Name: (6a,11b,16a)-2-Chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 2-chloroflumethasone
Manufacturers' Codes: C-48401-Ba
Molecular Formula: C22H27ClF2O5
Molecular Weight: 444.90
Percent Composition: C 59.39%, H 6.12%, Cl 7.97%, F 8.54%, O 17.98%
Literature References: Synthetic corticosteroid. Prepn: G. G. Anner et al., NL 540244; eidem, US 3652554; eidem, CH 551399, C.A. 81, 120864d (1974) (1968, 1972, 1974 all to Ciba-Geigy). Series of clinical trials in eczema, psoriasis, dermatomycoses, bacterial infections: J. Int. Med. Res. 11, Suppl. 1 (1983).
Properties: mp 220-222° (dec).
Melting point: mp 220-222° (dec)
Derivative Type: Monohydrate
Trademarks: Sicorten (Novartis)
Molecular Formula: C22H27ClF2O5.H2O
Molecular Weight: 462.91
Percent Composition: C 57.08%, H 6.31%, Cl 7.66%, F 8.21%, O 20.74%
Therap-Cat: Anti-inflammatory (topical); antipruritic.
Keywords: Antipruritic; Glucocorticoid. |