Title: Glisoxepid
CAS Registry Number: 25046-79-1
CAS Name: N-[2-[4-[[[[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-3-isoxazolecarboxamide
Additional Names: 1-(hexahydro-1H-azepin-1-yl)-3-[[p-[2-(5-methyl-3-isoxazolecarboxamido)ethyl]phenyl]sulfonyl]urea; 4-[4-[b-(5-methylisoxazole-3-carboxamido)ethyl]phenylsulfonyl]-1,1-hexamethylenesemicarbazide
Manufacturers' Codes: BS-4231; RP-22410
Trademarks: Pro-Diaban (Bayer; Schering AG)
Molecular Formula: C20H27N5O5S
Molecular Weight: 449.52
Percent Composition: C 53.44%, H 6.05%, N 15.58%, O 17.80%, S 7.13%
Literature References: Prepn: H. Plümpe, W. Puls, ZA 6806886; eidem, US 3668215 (1969, 1972 both to Bayer). Pharmacology: Loubatieres et al., C.R. Seances Acad. Sci. Ser. D 271, 1446 (1970); J. Pharmacol. 3, 171, 229 (1972). Toxicity study: Tettenborn, Arzneim.-Forsch. 24, 409 (1974). Series of articles: ibid. 363-452.
Properties: Colorless crystals from ethanol, mp 189°. LD50 in mice, rats, cats, dogs (g/kg): >10.0, >10.0, >4.0, >2.0 orally; in mice, rats (mg/kg): 283, 196 i.v. (Tettenborn).
Melting point: mp 189°
Toxicity data: LD50 in mice, rats, cats, dogs (g/kg): >10.0, >10.0, >4.0, >2.0 orally; in mice, rats (mg/kg): 283, 196 i.v. (Tettenborn)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives. |