Title: Gallium Citrate
CAS Registry Number: 27905-02-8; 30403-03-3 (unspecified stoichiometry)
CAS Name: 2-Hydroxy-1,2,3-propanetricarboxylic acid gallium salt (1:1)
Molecular Formula: C6H5GaO7
Molecular Weight: 258.82
Percent Composition: C 27.84%, H 1.95%, Ga 26.94%, O 43.27%
Line Formula: Ga(C6H5O7)
Literature References: Organogallium complex administered to provide an aqueous source of gallium that accumulates in specific biological tissues. Prepd from gallium hydroxide and citric acid: P. Neogi, S. K. Nandi, J. Indian Chem. Soc. 13, 399 (1936); H. C. Dudley, J. Am. Chem. Soc. 72, 3822 (1950). Review of early clinical use as radiolabeled form: J. I. Hirsch et al., Drug Intel. Clin. Pharm. 7, 519-523 (1973). Mechanism studies of tumor localization: S. R. Vallabhajosula et al., Int. J. Nucl. Med. Biol. 8, 363 (1981); and metabolism: H. Kriegel, Nuklearmedizin 2, 53 (1984). Clinical management of lymphoma with SPECT/CT system: B. Palumbo et al., Eur. J. Nucl. Med. Mol. Imaging 32, 1011 (2005). Toxicity studies: H. C. Dudley et al., J. Pharmacol. Exp. Ther. 98, 409 (1950); H. D. Brunner, et al., Radiology 61, 550 (1953). Review of diagnostic use as imaging agent in oncology: H. A. Macapinlac et al., Nucl. Med. Biol. 21, 731-738 (1994); in infection: C. J. Palestro, Semin. Nucl. Med. 24, 128-141 (1994); in lymphoma: E. Even-Sapir, O. Israel, Eur. J. Nucl. Med. Mol. Imaging 30, Suppl. 1, S65-S81 (2003).
Properties: Crystalline powder. Soly at 20° (g/100ml): water 92.4, 95% ethanol 0.12, abs ethanol 0.07. Insol in ether, benzene, acetone. LD50 i.v. in rats: >220 mg Ga/kg (Brunner).
Toxicity data: LD50 i.v. in rats: >220 mg Ga/kg (Brunner)
Derivative Type: 67Ga-Labeled form
CAS Registry Number: 41183-64-6
Therap-Cat: 67Ga-labeled form as diagnostic aid (radioactive imaging agent).
Keywords: Diagnostic Aid (Radioactive Imaging Agent). |