Title: GDNF
Additional Names: Glial cell line-derived neurotrophic factor
Literature References: Survival factor for dopaminergic neurons and spinal motoneurons. Prototype of a family of neurotrophic factors known as GDNF family ligands (GFL) which also includes neurturin, persephin, and artemin. Glycosylated, disulfide-linked homodimer; mol wt 40-45 kDa; structurally related to the TGF-b superfamily. Widely expressed in peripheral tissues and brain during embryonic and early postnatal development. Isoln from rat glial cells and prepn of recombinant human form: L. H. Lin et al., Science 260, 1130 (1993). Review of pharmacology and therapeutic potential: P. A. Lapchak, Rev. Neurosci. 7, 165-176 (1996); of neuroprotective and neurorestorative properties: D. M. Gash et al., Ann. Neurol. 44, Suppl. 1, S121-S125 (1998). Analgesic effect in neuropathic pain models: T. J. Boucher et al., Science 290, 124 (2000). Reviews: M. C. Bohn et al., Int. J. Dev. Neurosci. 18, 679-684 (2000); M. S. Airaksinen, M. Saarma, Nat. Rev. Neurosci.. 3, 383-394 (2002).
Derivative Type: Liatermin
CAS Registry Number: 188630-14-0
CAS Name: Methionyl neurotrophic factor (human glial-derived), dimer
Literature References: Production in E. coli by recombinant DNA technology: L. H. Lin et al., US 6093802 (2000 to Amgen). Clinical evaluation in Parkinson's disease: S. S. Gill et al., Nat. Med. 9, 589 (2003).
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