Title: Flunoxaprofen
CAS Registry Number: 66934-18-7
CAS Name: (aS)-2-(4-Fluorophenyl)-a-methyl-5-benzoxazoleacetic acid
Manufacturers' Codes: RV-12424
Trademarks: Priaxim (Ravizza)
Molecular Formula: C16H12FNO3
Molecular Weight: 285.27
Percent Composition: C 67.36%, H 4.24%, F 6.66%, N 4.91%, O 16.83%
Literature References: Nonsteroidal anti-inflammatory. Prepn of racemate: D. Evans et al., DE 2324443; eidem, US 3912748 (1973, 1975 both to Lilly). Prepn of racemate and anti-inflammatory activity: D. W. Dunwell et al., J. Med. Chem. 18, 53-58 (1975). Improved process for prepn of racemate and enantiomers: F. Mauri, R. Signorini, BE 877887; eidem, US 4304918 (1979, 1981 both to Ravizza); R. Signorini, A. Verga, DE 3325672 (1984 to Ravizza). HPLC determn of enantiomers in body fluids: S. Pedrazzini et al., J. Chromatogr. 415, 214 (1987). Prophylactic and therapeutic treatment of asthma and other immediate hypersensitivity diseases: W. Dawson, US 4416892 (1983 to Lilly).
Properties: Crystals from acetone-water or acetic acid, mp 162-164°. [a]D20 +50° (c = 2% in DMF). LD50 orally in mice: ~1200 mg/kg (Dunwell).
Melting point: mp 162-164°
Optical Rotation: [a]D20 +50° (c = 2% in DMF)
Toxicity data: LD50 orally in mice: ~1200 mg/kg (Dunwell)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives. |