Title: Fentiazac
CAS Registry Number: 18046-21-4
CAS Name: 4-(4-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid
Manufacturers' Codes: BR-700; CH-800
Trademarks: Donorest (Wyeth); Flogene (Polifarma); Norvedan (Wyeth)
Molecular Formula: C17H12ClNO2S
Molecular Weight: 329.80
Percent Composition: C 61.91%, H 3.67%, Cl 10.75%, N 4.25%, O 9.70%, S 9.72%
Literature References: Prepn: K. Brown, GB 1145884; idem, US 3476766 (both 1969 to Wyeth). Anti-inflammatory activity: K. Brown et al., Nature 219, 164 (1968). Crystallographic study: R. Destro, Acta Crystallogr. B34, 959 (1978). Absorption: G. Zanolo et al., Boll. Chim. Farm. 119, 209 (1980). Metabolism: S. Fumero et al., Arzneim.-Forsch. 30, 1253 (1980). Pharmacokinetics in humans: M. Quattrini et al., ibid. 31, 1046 (1981). Toxicity study: D. A. Shriver et al., Toxicol. Appl. Pharmacol. 42, 75 (1977). Review of exptl and clinical pharmacology: E. Marmo, Curr. Med. Res. Opin. 6, 53-63 (1979).
Properties: Colorless needles from benzene, mp 161-162°. LD50 in rats, mice (mg/kg): 661, 692 orally (Marmo).
Melting point: mp 161-162°
Toxicity data: LD50 in rats, mice (mg/kg): 661, 692 orally (Marmo)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives. |