Title: Fendiline
CAS Registry Number: 13042-18-7
CAS Name: g-Phenyl-N-(1-phenylethyl)benzenepropanamine
Additional Names: N-(3,3-diphenylpropyl)-a-methylbenzylamine; N-(1-phenylethyl)-3,3-diphenylpropylamine
Molecular Formula: C23H25N
Molecular Weight: 315.45
Percent Composition: C 87.57%, H 7.99%, N 4.44%
Literature References: Calcium blocking agent. Prepn: BE 621300; Harsányi et al., US 3262977 (1962, 1966 both to Chinoin); eidem, J. Med. Chem. 7, 623 (1964); Klosa, J. Prakt. Chem. 34, 312 (1966). Prepn and studies of the labelled compound: Volford, Harsányi, J. Labelled Compd. 9, 219 (1973). Structure-activity studies: Leszkovszky et al., Acta Physiol. Acad. Sci. Hung. 29, 283 (1966). Pharmacologic properties: W. R. Kukovetz et al., Arzneim.-Forsch. 26, 1321 (1976); A. Fleckenstein et al., ibid. 27, 562 (1977). Pharmacokinetics and tolerance: R. Weyhenmeyer et al., ibid. 37, 58 (1987). Use in ischemic heart disease: Z. Antaloczy, I. Preda, Ther. Hung. 27, 71 (1979). Assessment of Ca2+-antagonist effects: M. Spedding, Arch. Pharmacol. 318, 234 (1982).
Properties: bp0.3 206-210°.
Boiling point: bp0.3 206-210°
Derivative Type: Hydrochloride
CAS Registry Number: 13636-18-5
Manufacturers' Codes: HK-137
Trademarks: Cordan (IBI); Fendilar (SPA); Sensit (Thiemann)
Molecular Formula: C23H25N.HCl
Molecular Weight: 351.91
Percent Composition: C 78.50%, H 7.45%, N 3.98%, Cl 10.07%
Properties: Almost white or slightly pink powder, mp 204-205°. Very slightly sol in water; easily sol in methanol, ethanol, chloroform. LD50 in mice (mg/kg): 14.5 i.v.; 950 orally (Harsányi).
Melting point: mp 204-205°
Toxicity data: LD50 in mice (mg/kg): 14.5 i.v.; 950 orally (Harsányi)
Therap-Cat: Vasodilator (coronary).
Keywords: Calcium Channel Blocker; Arylalkylamines; Vasodilator (Coronary). |