Title: Fasciculins
CAS Registry Number: 86697-68-9
Additional Names: FAS
Literature References: Group of low molecular wt (~6750 Da) toxic peptides isolated from the venom of green mamba snakes. Allosterically inhibits (Ki ยป 10-10M) most synaptic acetylcholinesterases (AChE). Cationic peptides characterized by 4 disulphide bridges. Isoln from Dendroaspis angusticeps: D. Rodriguez-Ithurralde et al., Neurochem. Int. 5, 267 (1983). X-ray crystallography: M. H. le Du et al., J. Biol. Chem. 267, 22122 (1992). Inhibition of AChE: P. Fossier et al., Cell. Mol. Neurobiol. 6, 221 (1986). Allosteric control of inhibition: Z. Radic et al., J. Biol. Chem. 270, 20391 (1995). Amino acid sequence and structure-activity study: C. Cervenansky et al., Toxicon 34, 718 (1996). Review of neuropharmacology: F. Dajas et al., Methods Neurosci. 8, 258-270 (1992).
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