Title: Ethchlorvynol
CAS Registry Number: 113-18-8
CAS Name: 1-Chloro-3-ethyl-1-penten-4-yl-3-ol
Additional Names: 5-chloro-3-ethylpent-1-yn-4-en-3-ol; ethyl b-chlorovinyl ethynyl carbinol; ethclorvynol
Trademarks: Placidyl (Abbott); Arvynol (Pfizer); Serenesil (Abbott); Roeridorm (Roerig); Normoson
Molecular Formula: C7H9ClO
Molecular Weight: 144.60
Percent Composition: C 58.14%, H 6.27%, Cl 24.52%, O 11.06%
Literature References: Prepn: W. M. McLamore et al., J. Org. Chem. 20, 109 (1955); Bavley, McLamore, US 2746900 (1956 to Pfizer). Pharmacological studies: S. Y. P'an et al., J. Pharmacol. Exp. Ther. 114, 326 (1955). Pharmacodynamics: Y. C. Martin, Biochem. Pharmacol. 16, 2041 (1967). Evaluation as hypnotic: J. W. Middleton et al., Curr. Ther. Res. 8, 391 (1966); J. H. Pattison et al., J. Am. Geriatr. Soc. 20, 398 (1972). Study of metabolites: J. P. Horwitz et al., Drug Metab. Dispos. 8, 77 (1980).
Properties: Liquid, pungent aromatic odor. Slowly darkens on exposure to light and air. d425 1.065-1.070 (also reported as d420 1.070). bp760 173-174° (also reported as bp760 181°); bp0.1 28.5-30°. nD25 1.4675-1.4800. Immiscible with water; miscible with most organic solvents. LD50 in mice (mg/kg): 290 orally; 240 s.c. (P'an).
Boiling point: bp760 173-174°; also reported as bp760 181°; bp0.1 28.5-30°
Index of refraction: nD25 1.4675-1.4800
Density: d425 1.065-1.070; also reported as d420 1.070
Toxicity data: LD50 in mice (mg/kg): 290 orally; 240 s.c. (P'an)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Sedative; hypnotic.
Keywords: Sedative/Hypnotic; Alcohols. |