Title: Erythromycin Stearate
CAS Registry Number: 643-22-1
CAS Name: Erythromycin octadecanoate (salt)
Trademarks: Abboticine (Abbott); Bristamycin (BMS); Dowmycin E (Dow); Erypar (Parke-Davis); Eryprim (Scarium); Erythro S (Sanko); Erythrocin (Abbott); Ethril (BMS); Ethryn (Faulding); Gallimycin (Abbott); Meberyt; Pantomicina (Abbott); Pfizer-E (Pfizer); Wemid (Bernabo)
Molecular Formula: C55H103NO15
Molecular Weight: 1018.40
Percent Composition: C 64.87%, H 10.19%, N 1.38%, O 23.57%
Literature References: Semi-synthetic macrolide antibiotic. Prepn: O. F. Walasek, US 2881163 (1959 to Abbott). Bioavailability: A.-S. Malmborg, J. Antimicrob. Chemother. 5, 591 (1979). Pharmacokinetics and tolerance: D. C. Shanson et al., ibid. 14, 157 (1984). Clinical efficacy in respiratory tract infections: J. P. Butler et al., Chemotherapy (Basel) 25, 367 (1979); in acute otitis media: C. Rosen et al., Acta Otolaryngol. (Stockholm) Suppl. 407, 23 (1984). Prepn of erythromycin stearate (ester): Booth, Murray, US 2862921 (1958 to Upjohn).
Properties: Crystals. Slightly bitter taste. Slightly sol in alc, ether, chloroform. Practically insol in water.
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides. |