Title: Diacetazotol
CAS Registry Number: 83-63-6
CAS Name: N-Acetyl-N-[2-methyl-4-[(2-methylphenyl)azo]phenyl]acetamide
Additional Names: 4¢¢-(o-tolylazo)-o-diacetotoluidide; diacetylaminoazotoluene; N,N-diacetyl-o-tolyazo-o-toluidine; 2,3¢-dimethyl-4¢-(diacetylamino)azobenzene
Trademarks: Dermagan; Diacetotoluide; Dimazon; Pellidol
Molecular Formula: C18H19N3O2
Molecular Weight: 309.36
Percent Composition: C 69.88%, H 6.19%, N 13.58%, O 10.34%
Literature References: Prepd by treating aminoazotoluene with acetic anhydride or with acetyl chloride in the presence of sodium acetate: DE 253884 (1912 to Kalle); Ettel, Hebky, Collect. Czech. Chem. Commun. 13, 161 (1948). Biological properties: Rerábek et al., C.A. 46, 7234i (1952). Allergenic properties: Jirasek et al., Cesk. Dermatol. 41, 38 (1966).
Properties: Crystallizes in 2 modifications: Brick-red needles, mp 65°, or stout, red prisms, mp 75° (resembling crystals of potassium dichromate). The German Pharmacopoeia recognizes only a material with mp 74-76° (yellowish-red powder). Insol in water; sol in alcohol, benzene, chloroform, ether, acetone, fixed oils, fats, petrolatum.
Melting point: mp 65°; mp 75°; mp 74-76°
Derivative Type: Mixture with albumin and tetraiodopyrrole
Trademarks: Azodolen
Therap-Cat: Topical dermatologic.
Therap-Cat-Vet: Has been used in ointment or dusting powder to stimulate wound epitheliazation.
Status: This monograph has been retired and is no longer subject to revision or update. |