Title: Calciseptine CAS Registry Number: 134710-25-1 Literature References: Peptide toxin, 60 amino acids long with 4 disulfide bridges, isolated from the venom of the black mamba snake (Dendroaspis polylepis polylepis); specific blocker of L-type Ca2+ channels. Isoln and characterization: J. R. De Weille et al., Proc. Natl. Acad. Sci. USA 88, 2437 (1991). Solution synthesis: H. Kuroda et al., Peptide Res. 5, 265 (1992). NMR 3d structure determn: H. Haruyama et al., Bull. Magn. Reson. 18, 125 (1996). Analysis of residues involved in binding: R. M. Kini et al., Biochemistry 37, 9058 (1998). Differential sensitivities to L-channel subtypes: C. M. Rogers, E. R. Brown, Exp. Physiol. 86, 689 (2001). Comparison with 1,4-dihydropyridines of effects on smooth muscle: T. X. Watanbe et al., Jpn. J. Pharmacol. 68, 305 (1995); on skeletal muscle: M. C. Garcia et al., J. Membr. Biol. 184, 121 (2001). Use: Biochemical probe for L-type Ca2+ channels.

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