Title: Buzepide
CAS Registry Number: 3691-21-2
CAS Name: Hexahydro-a,a-diphenyl-1H-azepine-1-butanamide
Additional Names: 2,2-diphenyl-4-hexamethyleneiminobutyramide
Manufacturers' Codes: R-658
Molecular Formula: C22H28N2O
Molecular Weight: 336.47
Percent Composition: C 78.53%, H 8.39%, N 8.33%, O 4.76%
Literature References: Anticholinergic. Prepn: Janssen et al., J. Med. Pharm. Chem. 1, 187 (1959); of methiodide as well as free base: Janssen, de Jongh, US 2881165 (1959 to N.V. Nederlandsche Combinatie Chem. Ind.). Clinical trial in irritable bowel syndrome: J. Ph. Barbier et al., Ann. Gastroenterol. Hepatol. 25, 123 (1989).
Properties: Crystals from isopropanol, mp 141.5-143.5°.
Melting point: mp 141.5-143.5°
Derivative Type: Methiodide
CAS Registry Number: 15351-05-0
Additional Names: Metazepium iodide; 1-(3-carbamoyl-3,3-diphenylpropyl)hexahydro-1-methylazepinium iodide; N-(3,3-diphenyl-3-carbamoylpropyl)-N-methylperhydroazepinium iodide; diphexamide methiodide
Molecular Formula: C22H28N2O.CH3I
Molecular Weight: 478.41
Percent Composition: C 57.74%, H 6.53%, N 5.86%, O 3.34%, I 26.53%
Properties: Crystals, dec 212-213°.
Derivative Type: Mixture with haloperidol
Trademarks: Vésadol (Janssen)
Therap-Cat: Antispasmodic.
Keywords: Antimuscarinic; Antispasmodic. |