Title: Buthiazide
CAS Registry Number: 2043-38-1
CAS Name: 6-Chloro-3,4-dihydro-3-(2-methylpropyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-chloro-3,4-dihydro-3-isobutyl-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; thiabutazide; butizide; isobutylhydrochlorothiazide
Manufacturers' Codes: Su-6187; S-3500
Trademarks: Eunephran (Servier); Saltucin (Boehringer, Mann.)
Molecular Formula: C11H16ClN3O4S2
Molecular Weight: 353.85
Percent Composition: C 37.34%, H 4.56%, Cl 10.02%, N 11.88%, O 18.09%, S 18.12%
Literature References: Prepd from 5-chloro-2,4-disulfamoylaniline and isovaleraldehyde: Werner et al., J. Am. Chem. Soc. 82, 1161 (1960); GB 861367; GB 885078; G. de Stevens, L. H. Werner, US 3163645 (1961, 1961, 1964 all to Ciba); Topliss et al., J. Org. Chem. 26, 3842 (1961).
Properties: Crystals, mp 241-245° (Werner, 1960); from methanol + chloroform, mp 228° (Topliss). An ingredient of Modenol.
Melting point: mp 241-245° (Werner, 1960); mp 228° (Topliss)
Therap-Cat: Diuretic, antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs. |