Title: Bucloxic Acid
CAS Registry Number: 32808-51-8
CAS Name: 3-Chloro-4-cyclohexyl-a-oxobenzenebutanoic acid
Additional Names: 3-(3-chloro-4-cyclohexylbenzoyl)propionic acid; 4-(4-cyclohexyl-3-chlorophenyl)-4-oxobutyric acid; bucloxonic acid
Molecular Formula: C16H19ClO3
Molecular Weight: 294.77
Percent Composition: C 65.19%, H 6.50%, Cl 12.03%, O 16.28%
Literature References: Prepn: Krausz, Brunaud, DE 2021445 (1970 to Clin-Byla), C.A. 75, 5521d (1971); GB 1315542; Krausz et al., Arzneim.-Forsch. 24, 1360, 1364 (1974). Series of articles on pharmacology, metabolism, toxicity: ibid. 1368-1444. Toxicology: G. Mauzé et al., ibid. 1398.
Properties: Crystals from acetone, mp 163°. uv max (ethanol): 255 nm (e 15,500). LD50 in mice, rats (mg/kg): 900, 120 orally; 1100, 210 i.p (Krausz, p. 1360).
Melting point: mp 163°
Absorption maximum: uv max (ethanol): 255 nm (e 15,500)
Toxicity data: LD50 in mice, rats (mg/kg): 900, 120 orally; 1100, 210 i.p (Krausz, p. 1360)
Derivative Type: Calcium salt
CAS Registry Number: 32808-53-0
Manufacturers' Codes: CB-804
Trademarks: Esfar
Molecular Formula: C32H36CaCl2O6
Molecular Weight: 627.61
Percent Composition: C 61.24%, H 5.78%, Ca 6.39%, Cl 11.30%, O 15.30%
Properties: LD50 in male, female mice, rats (mg/kg): 1558, 1697, 195, 600-900 i.p.; 852, 1656, 176, 649 orally (Mauzé).
Toxicity data: LD50 in male, female mice, rats (mg/kg): 1558, 1697, 195, 600-900 i.p.; 852, 1656, 176, 649 orally (Mauzé)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update. |