Title: Aldrin
CAS Registry Number: 309-00-2
CAS Name: 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4:5,8-dimethanonaphthalene
Additional Names: HHDN
Manufacturers' Codes: compd 118
Trademarks: Octalene
Molecular Formula: C12H8Cl6
Molecular Weight: 364.91
Percent Composition: C 39.50%, H 2.21%, Cl 58.29%
Literature References: Chlorinated hydrocarbon insecticide; readily metabolized to dieldrin, q.v. Activity: C. W. Kearns et al., J. Econ. Entomol. 42, 127 (1949). Prepn of aldrin and endo,endo-isomer: Lidov, US 2635977 (1953 to Shell). Alternate syntheses: Schmerling, US 2911447 (1959 to Universal Oil Prod.); Korte, Rechmeier, Ann. 656, 131 (1962). Toxicity study: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969). Review of toxicology and human exposure: Toxicological Profile for Aldrin/Dieldrin (PB2003-100134, 2002) 354 pp.
Properties: Crystals, mp 104°. Vapor pressure at 20°: 7.5´10-5 mm Hg. Very sol in most organic solvents. Practically insol in water. Stable in presence of organic and inorganic alkalies; stable to the action of hydrated metal chlorides. LD50 in male, female rats (mg/kg): 39, 60 orally (Gaines).
Melting point: mp 104°
Toxicity data: LD50 in male, female rats (mg/kg): 39, 60 orally (Gaines)
Derivative Type: endo,endo-Isomer
Additional Names: Isodrin
Manufacturers' Codes: compd 711
Properties: Crystals, mp 240-242°. LD50 in male, female rats (mg/kg): 15, 7.0 orally (Gaines).
Melting point: mp 240-242°
Toxicity data: LD50 in male, female rats (mg/kg): 15, 7.0 orally (Gaines)
CAUTION: Potential symptoms of overexposure by ingestion, inhalation, or skin absorption are headache, dizziness; nausea, vomitting, malaise; myoclinic limb jerks; clonic and tonic convulsions; coma; hematuria, azotemia. Potential occupational carcinogen. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 2003) p 8; Patty's Industrial Hygiene and Toxicology vol. 2B, G. D. Clayton, F. E. Clayton, Eds. (Wiley-Interscience, New York, 4th ed., 1994) pp 1517-1523.
Use: Formerly as insecticide. |